A 24-Gene Predictor of Response to Postoperative Radiation Therapy in Prostate Cancer
نویسندگان
چکیده
منابع مشابه
Postoperative Radiation Therapy for Prostate Cancer
Prostate cancer is a common problem for US men. Once patients are initially diagnosed, they are often treated with either surgery or radiation therapy. For those whose initial treatment is radical prostatectomy, recurrences of cancer can be detected at an early stage by monitoring the blood levels of prostatic specific antigen (PSA). Once the PSA level becomes detectable, radiation therapy deli...
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Background and purpose: Radiation therapy as a part of cancer treatment is used in almost 50-60% of involved cases. In prostate cancer radiation therapy, a large volume of pelvis is irradiated, so, it is necessary to preserve sensitive organs around the treatment area, especially rectum and bladder. In this study, some dosimetric parameters such as minimum dose (Dmin), maximum dose (Dmax), mean...
متن کاملRe: Development and Validation of a 24-Gene Predictor of Response to Postoperative Radiotherapy in Prostate Cancer: A Matched, Retrospective Analysis.
BACKGROUND Postoperative radiotherapy has an important role in the treatment of prostate cancer, but personalised patient selection could improve outcomes and spare unnecessary toxicity. We aimed to develop and validate a gene expression signature to predict which patients would benefit most from postoperative radiotherapy. METHODS Patients were eligible for this matched, retrospective study ...
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Background: Lithium is a therapeutic option for the treatment of the acute phase of the bipolar disorder and long-term management of this disorder. However, it is estimated that 10 to 60% of patients do not properly response to this medication. Methods: To investigate the role of MARK2 gene in response to lithium, we genotyped the MARK2 rs10792421 polymorphism in Iranian bipolar pa...
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Introduction: Recently, magnetic resonance spectroscopic imaging (MRSI), as a functional imaging method, has been used for clinical target volume definition. In this study, we used this method to define the target volume in prostate radiotherapy. Material and Method: In this study, we used images of 20 prostate cancer cases. MRSI and MRI images were fused with CT images. Then, treatment plannin...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2016
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2016.06.258